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A novel MRI analysis technique provides assessment of the effectiveness of liver cancer treatment far sooner than existing methods, according to preliminary results of a study presented at RSNA 2015.
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Many patients undergo treatment with transarterial chemoembolization (TACE), an image-guided procedure that blocks the tumor’s blood supply while delivering chemotherapeutic drugs directly to the tumor. Identifying patients who don’t respond to TACE is critical so that they can be treated again or have their therapy changed in a timely fashion.
“In clinical oncology, it is very challenging to assess tumor response to treatment,” said study co-author Julius Chapiro, M.D., of the Yale University School of Medicine. “Up until now, we could measure the extent of tumor diameter or uptake with manual tools like the caliper on the screen, which are highly unreliable due to reader bias.”
Dr. Chapiro and colleagues used the quantitative European Association for the Study of the Liver (qEASL) technique, a new 3-D approach the researchers developed in collaboration with Philips Research North America that provides whole liver volumetric enhancement quantification on MRI.
“The radiologist can segment the entire tumor with the assistance of the computer,” Dr. Chapiro said. “It’s a work-flow efficient, semi-automated process that takes 15 to 20 seconds to segment and allows you to delineate the tumor in 3-D.”
The researchers used qEASL on 68 liver cancer patients with infiltrative HCC to measure treatment response and predict survival. The ill-defined borders and the sheer number of lesions in infiltrative HCC can pose a challenge in treatment response assessment after TACE with traditional methods.
“Up until now we haven’t had any kind of objective measurement for infiltrative liver cancer,” said study co-author Susanne Smolka, one of several medical...
Μοναδικό: Η Πρώτη Live Επέμβαση Εγκεφάλου σε Ασθενή με Ασθένεια Πάρκινσον μεταδόθηκε στην Τηλεόραση σε 171 χώρες (βίντεο)
National Geographic - Brain Surgery Live (2015)